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These social determinants are tobacco and tobacco products, indoor and outdoor pollution, occupational exposures, infections, low education and socioeconomic status, and poverty

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Of these, nine studies were excluded because of: a lack of specification regarding whether mothers were exposed to passive or active smoking (seven studies), focusing on the genetic effects of smoking on newborns (one study) and an overlapping population (one study) (Supplementary file Figure 1)

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Rutika Mehta, an oncologist in the Gastrointestinal Oncology Program at Tampa's Moffitt Cancer Center